Augmentation of Self-Interference Cancellation for Full-Duplex using NARX Neural Networks

A self-interference cancellation augmentation technique based on a NARX (Nonlinear Autoregressive Exogenous) network model is implemented and evaluated on an OFDM-based full-duplex system testbed operating at 2.4 GHz. In a comparison with the state-of-the-art polynomial models, our experimental results demonstrate the significant computational efficiency of the proposed NARX model. Specifically, the NARX model with one hidden layer reduces computations by 83.3% while achieving the same cancellation level within a bandwidth of 2 MHz

The role of the SGK3/TOPK signaling pathway in the transition from acute kidney injury to chronic kidney disease

Introduction: Profibrotic phenotype of renal tubular epithelial cells (TECs) featured with epithelial to mesenchymal transition (EMT) and profibrotic factors secretion, and aberrant accumulation of CD206+ M2 macrophages are the key points in the transition from acute kidney injury (AKI) to chronic kidney disease (CKD). Nevertheless, the underlying mechanisms involved remain incompletely understood. Serum and glucocorticoid-inducible kinase (SGK) is a serine/threonine protein kinase, required for intestinal nutrient transport and ion channels modulation. T-LAK-cell-originated protein kinase (TOPK) is a member of the mitogen activated protein kinase family, linked to cell cycle regulation. However, little is known about their roles in AKI-CKD transition.Methods: In this study, three models were constructed in C57BL/6 mice: low dose and multiple intraperitoneal injection of cisplatin, 5/6 nephrectomy and unilateral ureteral obstruction model. Rat renal tubular epithelial cells (NRK-52E) were dealt with cisplatin to induce profibrotic phenotype, while a mouse monocytic cell line (RAW264.7) were cultured with cisplatin or TGF-β1 to induce M1 or M2 macrophage polarization respectively. And co-cultured NRK-52E and RAW264.7 through transwell plate to explore the interaction between them. The expression of SGK3 and TOPK phosphorylation were detected by immunohistochemistry, immunofluorescence and western blot analysis.Results:In vivo, the expression of SGK3 and p-TOPK were gradually inhibited in TECs, but enhanced in CD206+ M2 macrophages. In vitro, SGK3 inhibition aggravated epithelial to mesenchymal transition through reducing the phosphorylation state of TOPK, and controlling TGF-β1 synthesis and secretion in TECs. However, SGK3/TOPK axis activation promoted CD206+ M2 macrophage polarization, which caused kidney fibrosis by mediating macrophage to myofibroblast transition (MMT). When co-cultured, the TGF-β1 from profibrotic TECs evoked CD206+ M2 macrophage polarization and MMT, which could be attenuated by SGK3/TOPK axis inhibition in macrophages. Conversely, SGK3/TOPK signaling pathway activation in TECs could reverse CD206+ M2 macrophages aggravated EMT.Discussion: We revealed for the first time that SGK3 regulated TOPK phosphorylation to mediate TECs profibrotic phenotype, macrophage plasticity and the crosstalk between TECs and macrophages during AKI-CKD transition. Our results demonstrated the inverse effect of SGK3/TOPK signaling pathway in profibrotic TECs and CD206+ M2 macrophages polarization during the AKI-CKD transition

Simulating soil salinity dynamics, cotton yield and evapotranspiration under drip irrigation by ensemble machine learning

We thank the China Scholarship Council (CSC) for providing a scholarship (202206710073) to Zewei Jiang. This work was supported by the Fundamental Research Funds for the Central Universities (B220203009), the Postgraduate Research & Practice Program of Jiangsu Province (KYCX22_0669), the Water Conservancy Science and Technology Project of Jiangxi Province (201921ZDKT06, 202124ZDKT09), the National Natural Science Foundation of China (51879076), the Fundamental Research Funds for the Central Universities (B210204016), Science & Technology Specific Projects in Agricultural High-tech Industrial Demonstration Area of the Yellow River Delta, Grant No: 2022SZX01.Peer reviewedPublisher PD

Fracture Propagation Behavior of Bedding Shale in the Process of Multistage Cluster Fracturing considering the Intercluster Stress Interference

AbstractStaged multicluster fracturing in horizontal wells is the key technology for forming complex fractures in shale reservoirs. The existence of shale bedding plays a conspicuous role for the propagation path of hydraulic fractures, affecting the propagation of the fracture height direction prominently. A 3D finite element model containing three clusters signed as side clusters and middle cluster was established based on the cohesive zone model and the dynamic distribution mechanism of interfracture flow. And the correctness of the model was verified by literature comparison. Some factors including cluster spacing, horizontal stress difference, shale bedding strength, perforation density, injection rate, and viscosity of fracturing fluid which influenced fracture propagation behavior of bedding shale were simulated. The results indicate that the stress interference of the middle cluster by the clusters on both sides will be prominently obvious when the cluster spacing is less than 10 m. Multiclusters will penetrate across the shale bedding when the horizontal stress difference is more than 4 MP, which will conspicuously reduce the activated probability of discontinuities and the complexity of fracture geometry. In correspondence with increase of horizontal stress difference, the interference between clusters also increases prominently, which will conspicuously decrease the propagation of the middle cluster. In order to comprehensively equalize the length of multiclusters, the inhibition of intercluster stress interference on the middle cluster propagation can be counteracted by improving pressure drop in perforation. The high injection rate and viscosity of fracturing fluid will contribute to the shale bedding shear slip increasingly, which is conducive to the formation of complex fractures in areas with well-developed bedding. The study has a certain guiding significance for the operation parameter design of multicluster fracturing in bedded shale

Does temporary transfer to preoperative hemodialysis influence postoperative outcomes in patients on peritoneal dialysis? A retrospective cohort study

BackgroundThe associations between preoperative transfer to hemodialysis (HD) and postoperative outcomes in patients on chronic peritoneal dialysis (PD) remain unknown. We conducted this retrospective cohort study to investigate whether preoperative HD could influence surgical outcomes in PD patients undergoing major surgeries.MethodsAll chronic PD patients who underwent major surgeries from January 1, 2007, to December 31, 2020, at Peking University First Hospital were screened. Major surgery was defined as surgical procedures under general, lumbar or epidural anesthesia, with more than an overnight hospital stay. Patients under the age of 18, with a dialysis duration of less than 3 months, and those who underwent renal implantation surgeries and procedures exclusively aimed at placing or removing PD catheters were excluded. Patients involved were divided into either HD or PD group based on their preoperative dialysis status for further analysis.ResultsOf 105 PD patients enrolled, 65 continued PD, and 40 switched to HD preoperatively. Patients with preoperative HD were significantly more likely to develop postoperative hyperkalemia. The total complication rates were numerically higher in patients undergoing preoperative HD. After adjustment, the incidence of postoperative hyperkalemia or any other postoperative complication rates were similar between groups. There were no differences in long-term survival between the two groups.ConclusionsIt does not seem indispensable for PD patients to switch to temporary HD before major surgeries